CXR Biosciences

THE INVESTIGATIVE & EXPLORATORY TOXICOLOGY COMPANY

CXR Biosciences uses its extensive Investigative Toxicology experience to evaluate toxicological processes across species, and determine the relevance to humans.

CXR’S COLLABORATIVE AND ADVISORY APPROACH, TOXICOLOGICAL EXPERTISE AND EXTENSIVE LABORATORY CAPABILITIES HAVE HELPED CUSTOMERS OF ALL SIZES RESOLVE ISSUES RELATING TO THE SAFETY OF COMPOUNDS OR SELECTION OF DRUG OR CHEMICAL CANDIDATES.

Our customers include leading pharmaceutical, agrochemical, chemical, consumer product and biotechnology companies. We provide Investigative Toxicology, Exploratory & Discovery Toxicology, Metabolism & PK/TK and Dermal Absorption services and expertise on a contract research basis.

CXR employs over 35 staff recruited from both industrial and academic backgrounds, over 30% of whom have PhDs. The combination of academic excellence together with extensive industrial experience in pharmaceutical, agrochemical and chemical toxicology, metabolism and pharmacokinetics leads to a uniquely skilled investigative toxicology and preclinical development service.

To date, we have helped over 60 companies/consortia of all sizes across a broad range of different sectors including global pharmaceutical, biotech, agrochemical, consumer product, industrial chemical and fine chemical companies. These have included: BASF, Bayer, Dow Agrochemical, DuPont, Monsanto, Syngenta, ExxonMobil, AstraZeneca, Sanofi-Aventis, Pfizer, Roche, Procter & Gamble, Cancer Research Technology, Ineos Fluor, Ineos Chlor, 3M, Plastics Europe and ECPI.

INVESTIGATIVE & MECHANISTIC TOXICOLOGY

We are experts in the design, performance and interpretation of preclinical investigative and mechanistic toxicology programs. These programs are typically intended to explain the toxicological mode of action / adverse outcome pathway (AOP) affected by the compound under investigation. Using this knowledge, we explain previously observed preclinical toxicities and evaluate the actual hazard and/or risk to humans.

EXPLORATORY & DISCOVERY TOXICOLOGY

In order to improve R&D productivity, identification of potential toxic hazard and quantification of potential risk is shifting from the development stage to the research stage of R&D – hence this discipline is also termed predictive toxicology.

METABOLISM, ABSORPTION & PK/TK

CXR works with agrochemical, chemical and pharmaceutical companies to generate PK/TK, metabolism and absorption data for even the most challenging compounds and mixtures.

DERMAL ABSORPTION

In response to customer demand, CXR now provides in vitro dermal absorption studies to GLP. These studies are used to predict human exposure, and are required for the safety testing of topically applied pharmaceuticals, new and re-registered agrochemicals, consumer products and chemicals. CXR will assist in designing and interpreting an appropriate study for screening, bioequivalence or registration support.

AGROCHEMICAL

Crop Protection, XXR has provided exploratory toxicology and investigative toxicology services to the agrochemical industry for many years.

PHARMACEUTICAL & BIOTECH

CXR works with pharmaceutical and biotechnology companies to support discovery toxicology and investigative toxicology programs.

CHEMICAL

CXR has provided investigative toxicology, metabolism, absorption and read-across services to the chemicals industry for many years.

CONSUMER PRODUCTS

CXR has expertise in elucidating potential mechanisms of toxicity of marketed consumer products, & of using primary cell culture and genomics to support product claims.